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如何克服长序列处理时的内存溢出问题?

2025-09-05 1.8 K

百万碱基级序列的稳定处理方法

处理100万碱基以上的超长序列时,推荐采用分段压缩处理策略:

  1. Hardware layer optimization::
    • 启用NVIDIA的FlashAttention-2(需在configs/model.yamlset up
      use_flash_attn: true

      )

    • 配置梯度检查点:gradient_checkpointing: true
  2. Algorithmic Layer Optimization::
    • 采用滑动窗口法(设置chunk_size=50000)
    • 激活内存复用模式:enable_memory_efficient=True
  3. 数据层优化::
    • utilizationZarr格式存储压缩序列数据
    • 预先运行python -m evo2.utils.preprocess --compress进行序列压缩

紧急方案:当遇到CUDA out of memory错误时,立即添加torch.cuda.empty_cache()清理显存

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