Evo 2's zero-sample prediction capability
An important feature of Evo 2 is its zero-sample variant effect prediction capability. This means that the model can directly predict the biological effects of gene variants without additional training for a specific task.
In practice, the user simply enters the reference and variant sequences and the model outputs their respective scores. By comparing these scores, researchers can assess the potential impact of a particular variant (e.g., BRCA1 gene mutation) on function.
This feature greatly simplifies the research workflow and avoids the tedious process of traditional methods that require training specialized models for each new variant.
This answer comes from the articleEvo2: An Open Source BioAI Tool to Support Genome Modeling and DesignThe
